Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 31 Researches
7.4
USERS' SCORE
Good
Based on 5 Reviews
8.3
Supplement Facts
Serving Size: 1 Wafer
Amount Per Serving
%DV
Total Carbohydrate
1 g
<1%**
Total Sugars
<1 g
***
Includes <1 g Added Sugars
1%**
Lactobacillus BlendWhich contains 1 Billion Live Culture CFULactobacillus acidophilus La-14® and Bifidobacterium lactis BI-04
4.5 mg
***
Top Medical Research Studies
9.5
In our clinical trial, we examined the effects of a probiotic combination of Lactobacillus acidophilus and L. plantarum on patients with diarrhea-predominant irritable bowel syndrome (IBS-D). We randomly assigned 100 participants to standard IBS treatment or the same treatment plus probiotics over 12 weeks.
Both groups experienced significant symptom relief, but those taking probiotics saw even greater improvements. By the end of the study, everyone in the probiotic group achieved either complete remission or mild symptoms, while some in the standard treatment group still reported moderate issues. These results suggest that adding probiotics could enhance IBS management strategies.
Both groups experienced significant symptom relief, but those taking probiotics saw even greater improvements. By the end of the study, everyone in the probiotic group achieved either complete remission or mild symptoms, while some in the standard treatment group still reported moderate issues. These results suggest that adding probiotics could enhance IBS management strategies.
Read More
7
We explored the effectiveness of a two-strain mixture of Lactobacillus acidophilus for patients with irritable bowel syndrome over eight weeks. In a well-structured trial involving 80 participants, we compared the probiotic to a placebo.
While both groups reported improvements in abdominal pain, we didn’t find significant differences between them regarding pain relief. However, the acidophilus group experienced notable reductions in flatus and overall discomfort.
This suggests that Lactobacillus acidophilus could be a valuable option for symptom management despite no major advantages in abdominal pain.
While both groups reported improvements in abdominal pain, we didn’t find significant differences between them regarding pain relief. However, the acidophilus group experienced notable reductions in flatus and overall discomfort.
This suggests that Lactobacillus acidophilus could be a valuable option for symptom management despite no major advantages in abdominal pain.
Read More
9
We investigated the effects of two probiotic strains, DDS-1 and UABla-12, on abdominal pain and symptoms in people with irritable bowel syndrome (IBS). In a well-structured study involving 330 participants, those receiving probiotics experienced significant improvements in pain severity compared to a placebo group.
The DDS-1 strain showed a 52.3% response rate, while UABla-12 had a 28.2% response. Both probiotics also improved overall IBS symptoms, bowel consistency, and quality of life measures.
These findings suggest that probiotics could be a beneficial option for managing IBS symptoms.
The DDS-1 strain showed a 52.3% response rate, while UABla-12 had a 28.2% response. Both probiotics also improved overall IBS symptoms, bowel consistency, and quality of life measures.
These findings suggest that probiotics could be a beneficial option for managing IBS symptoms.
Read More
Most Useful Reviews
9
Helps bowel movement
4 people found this helpful
I have used this brand for over five years. It is excellent for the immune system and incredibly effective for my irritable bowel syndrome. Although this is a new version, it works just as well as the old one. My six-year-old grandson is also using it, and it has helped his breathing issues related to the cold air. I highly recommend this product; you will be pleased and likely use it for years to come.
Read More
7.5
Improves bowel regularity
1 people found this helpful
It’s quite good; I have regular bowel movements now, whereas I was often constipated before. This product has markedly improved my irritable bowel syndrome.
Read More
7.5
Bowel movement improvement
The tablet is slightly larger, round, and quite palatable with a hint of strawberry yogurt flavour. It’s easy to ingest daily, and I have noticed improvements in my bowel movements, which has helped my irritable bowel syndrome. I recommend it for both children and women.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 31 Researches
7.4
- All Researches
9.5
In our clinical trial, we examined the effects of a probiotic combination of Lactobacillus acidophilus and L. plantarum on patients with diarrhea-predominant irritable bowel syndrome (IBS-D). We randomly assigned 100 participants to standard IBS treatment or the same treatment plus probiotics over 12 weeks.
Both groups experienced significant symptom relief, but those taking probiotics saw even greater improvements. By the end of the study, everyone in the probiotic group achieved either complete remission or mild symptoms, while some in the standard treatment group still reported moderate issues. These results suggest that adding probiotics could enhance IBS management strategies.
Both groups experienced significant symptom relief, but those taking probiotics saw even greater improvements. By the end of the study, everyone in the probiotic group achieved either complete remission or mild symptoms, while some in the standard treatment group still reported moderate issues. These results suggest that adding probiotics could enhance IBS management strategies.
Read More
9.5
This randomized, single-blinded trial evaluated the impact of probiotics, specifically Lactobacillus acidophilus and plantarum, on patients with diarrhea-predominant irritable bowel syndrome (IBS-D).
We found that when added to standard IBS treatment, these probiotics significantly improved symptoms over a 12-week period.
Group B, the probiotic group, experienced better results, including fewer days with pain and greater satisfaction with bowel habits. While both groups saw reductions in IBS severity, the probiotics led to complete remission in many patients, which is promising for future treatment guidelines.
We found that when added to standard IBS treatment, these probiotics significantly improved symptoms over a 12-week period.
Group B, the probiotic group, experienced better results, including fewer days with pain and greater satisfaction with bowel habits. While both groups saw reductions in IBS severity, the probiotics led to complete remission in many patients, which is promising for future treatment guidelines.
Read More
9
Probiotic milk improves IBS symptoms
We examined the effects of a daily cultured milk drink containing Lactobacillus acidophilus on individuals with constipation-predominant irritable bowel syndrome (IBS-C). Over 30 days, participants reported significant relief in constipation symptoms alongside improved intestinal transit time and decreased fecal pH.
Notably, the pro-inflammatory cytokines levels also dropped significantly, indicating a positive immune response. These results suggest that incorporating probiotic-rich cultured milk drinks might serve as a helpful addition to treat this condition effectively.
Notably, the pro-inflammatory cytokines levels also dropped significantly, indicating a positive immune response. These results suggest that incorporating probiotic-rich cultured milk drinks might serve as a helpful addition to treat this condition effectively.
Read More
9
We investigated the effects of two probiotic strains, DDS-1 and UABla-12, on abdominal pain and symptoms in people with irritable bowel syndrome (IBS). In a well-structured study involving 330 participants, those receiving probiotics experienced significant improvements in pain severity compared to a placebo group.
The DDS-1 strain showed a 52.3% response rate, while UABla-12 had a 28.2% response. Both probiotics also improved overall IBS symptoms, bowel consistency, and quality of life measures.
These findings suggest that probiotics could be a beneficial option for managing IBS symptoms.
The DDS-1 strain showed a 52.3% response rate, while UABla-12 had a 28.2% response. Both probiotics also improved overall IBS symptoms, bowel consistency, and quality of life measures.
These findings suggest that probiotics could be a beneficial option for managing IBS symptoms.
Read More
9
We investigated how probiotics impact symptoms of irritable bowel syndrome (IBS), especially in patients with small intestinal bacterial overgrowth (SIBO).
In a unique study featuring 26 IBS patients, those with SIBO experienced a remarkable 71.3% reduction in symptoms after taking a specific probiotic mix for 30 days.
Meanwhile, patients without SIBO showed only a 10.6% decrease. We noted significant improvements in satisfaction with bowel function, particularly in those with constipation-predominant IBS, regardless of SIBO status.
In a unique study featuring 26 IBS patients, those with SIBO experienced a remarkable 71.3% reduction in symptoms after taking a specific probiotic mix for 30 days.
Meanwhile, patients without SIBO showed only a 10.6% decrease. We noted significant improvements in satisfaction with bowel function, particularly in those with constipation-predominant IBS, regardless of SIBO status.
Read More
User Reviews
USERS' SCORE
Good
Based on 5 Reviews
8.3
- All Reviews
- Positive Reviews
- Negative Reviews
9
Helps bowel movement
4 people found this helpful
I have used this brand for over five years. It is excellent for the immune system and incredibly effective for my irritable bowel syndrome. Although this is a new version, it works just as well as the old one. My six-year-old grandson is also using it, and it has helped his breathing issues related to the cold air. I highly recommend this product; you will be pleased and likely use it for years to come.
Read More
7.5
Improves bowel regularity
1 people found this helpful
It’s quite good; I have regular bowel movements now, whereas I was often constipated before. This product has markedly improved my irritable bowel syndrome.
Read More
7.5
Bowel movement improvement
The tablet is slightly larger, round, and quite palatable with a hint of strawberry yogurt flavour. It’s easy to ingest daily, and I have noticed improvements in my bowel movements, which has helped my irritable bowel syndrome. I recommend it for both children and women.
Read More
7.5
Body feels lighter
I am a repeat customer of this product and highly recommend it. It has improved my bowel movements significantly, and I feel lighter overall, which has been beneficial for my irritable bowel syndrome.
Read More
7.5
Taste and efficiency
The taste is pleasant, and I am very satisfied. My bowel movements have improved, helping with my irritable bowel syndrome. I will continue using this product.
Read More
Frequently Asked Questions
7.5
Improves bowel regularity
1 people found this helpful
It’s quite good; I have regular bowel movements now, whereas I was often constipated before. This product has markedly improved my irritable bowel syndrome.
7.5
Body feels lighter
I am a repeat customer of this product and highly recommend it. It has improved my bowel movements significantly, and I feel lighter overall, which has been beneficial for my irritable bowel syndrome.
9
Helps bowel movement
4 people found this helpful
I have used this brand for over five years. It is excellent for the immune system and incredibly effective for my irritable bowel syndrome. Although this is a new version, it works just as well as the old one. My six-year-old grandson is also using it, and it has helped his breathing issues related to the cold air. I highly recommend this product; you will be pleased and likely use it for years to come.
7.5
Bowel movement improvement
The tablet is slightly larger, round, and quite palatable with a hint of strawberry yogurt flavour. It’s easy to ingest daily, and I have noticed improvements in my bowel movements, which has helped my irritable bowel syndrome. I recommend it for both children and women.
7.5
Taste and efficiency
The taste is pleasant, and I am very satisfied. My bowel movements have improved, helping with my irritable bowel syndrome. I will continue using this product.
9.5
In our clinical trial, we examined the effects of a probiotic combination of Lactobacillus acidophilus and L. plantarum on patients with diarrhea-predominant irritable bowel syndrome (IBS-D). We randomly assigned 100 participants to standard IBS treatment or the same treatment plus probiotics over 12 weeks.
Both groups experienced significant symptom relief, but those taking probiotics saw even greater improvements. By the end of the study, everyone in the probiotic group achieved either complete remission or mild symptoms, while some in the standard treatment group still reported moderate issues. These results suggest that adding probiotics could enhance IBS management strategies.
Both groups experienced significant symptom relief, but those taking probiotics saw even greater improvements. By the end of the study, everyone in the probiotic group achieved either complete remission or mild symptoms, while some in the standard treatment group still reported moderate issues. These results suggest that adding probiotics could enhance IBS management strategies.
8
We investigated the impact of multispecies probiotics, including Lactobacillus acidophilus, in treating irritable bowel syndrome (IBS). In a randomized, double-blind study with 49 participants, those taking probiotics experienced significantly more symptom relief than those on a placebo after four weeks.
The probiotics not only eased abdominal discomfort and bloating but also positively altered gut bacteria. Our findings suggest that multispecies probiotics could be a valuable option for managing IBS symptoms.
The probiotics not only eased abdominal discomfort and bloating but also positively altered gut bacteria. Our findings suggest that multispecies probiotics could be a valuable option for managing IBS symptoms.
7
We explored the effectiveness of a multi-species probiotic mixture on IBS symptoms in a study involving 81 patients. Participants were divided to receive either the probiotic mix—featuring Lactobacillus acidophilus and other strains—or a placebo for four weeks.
While the probiotics did boost levels of beneficial bacteria, the overall relief from IBS symptoms didn’t significantly differ from the placebo. However, those taking probiotics reported improved scores specifically for diarrhea. This suggests a potential for certain probiotics to help manage some IBS symptoms, although results were mixed.
While the probiotics did boost levels of beneficial bacteria, the overall relief from IBS symptoms didn’t significantly differ from the placebo. However, those taking probiotics reported improved scores specifically for diarrhea. This suggests a potential for certain probiotics to help manage some IBS symptoms, although results were mixed.
References
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- Sarkawi M, Raja Ali RA, Abdul Wahab N, Abdul Rathi ND, Mokhtar NM. A randomized, double-blinded, placebo-controlled clinical trial on Lactobacillus-containing cultured milk drink as adjuvant therapy for depression in irritable bowel syndrome. Sci Rep. 2024;14:9478. doi:10.1038/s41598-024-60029-2
- Shanshal SA, Alsaaty MH, Al-Qazaz H, Al-Zidan RN. Two Lactobacilli strains as adjuvant therapy in the management of irritable bowel syndrome: a randomized control trial. Ceska Slov Farm. 2024;72:233.
- Chang YH, Choi YJ, Shin CM, Moon JS, Kim TY, et al. Efficacy of Quadruple-coated Probiotics in Patients With Irritable Bowel Syndrome: A Randomized, Double-blind, Placebo-controlled, Parallel-group Study. J Neurogastroenterol Motil. 2024;30:73. doi:10.5056/jnm23036
- Drozdov VN, Shikh EV, Astapovskii AA, Khalaidzheva KN, Solovieva SA, et al. [Clinical efficacy of a modern probiotic for the correction of intestinal microflora in patients with irritable bowel syndrome with diarrhea and antibiotic-associated diarrhea]. Vopr Pitan. 2023;92:92. doi:10.33029/0042-8833-2023-92-4-92-103
- Cocetta V, Giacomini I, Tinazzi M, Berretta M, Quagliariello V, et al. Maintenance of intestinal epithelial barrier integrity by a combination of probiotics, herbal extract, and vitamins. Minerva Pediatr (Torino). 2023. doi:10.23736/S2724-5276.23.07128-8
- Mokhtar NM, Jaafar NM, Alfian E, Mohd Rathi ND, Abdul Rani R, et al. Clinical assessment and cytokines level in constipation-predominant irritable bowel syndrome participants treated with Lactobacillus-containing cultured milk drink. Acta Gastroenterol Belg. 2021;84:585. doi:10.51821/84.4.009
- Skrzydło-Radomańska B, Prozorow-Król B, Cichoż-Lach H, Majsiak E, Bierła JB, et al. The Effectiveness of Synbiotic Preparation Containing and Probiotic Strains and Short Chain Fructooligosaccharides in Patients with Diarrhea Predominant Irritable Bowel Syndrome-A Randomized Double-Blind, Placebo-Controlled Study. Nutrients. 2020;12. doi:10.3390/nu12071999
- Maixent JM, Pons O, Sennoune SR, Sadrin S. Clinical effects of Lactobacillus strains as probiotics in the treatment of irritable bowel syndrome. Results from the LAPIBSS trial: Future objectives. Cell Mol Biol (Noisy-le-grand). 2020;66:211.
- Martoni CJ, Srivastava S, Leyer GJ. DDS-1 and UABla-12 Improve Abdominal Pain Severity and Symptomology in Irritable Bowel Syndrome: Randomized Controlled Trial. Nutrients. 2020;12. doi:10.3390/nu12020363
- Sadrin S, Sennoune S, Gout B, Marque S, Moreau J, et al. A 2-strain mixture of Lactobacillus acidophilus in the treatment of irritable bowel syndrome: A placebo-controlled randomized clinical trial. Dig Liver Dis. 2020;52:534. doi:10.1016/j.dld.2019.12.009
- Preston K, Krumian R, Hattner J, de Montigny D, Stewart M, et al. Lactobacillus acidophilus CL1285, Lactobacillus casei LBC80R and Lactobacillus rhamnosus CLR2 improve quality-of-life and IBS symptoms: a double-blind, randomised, placebo-controlled study. Benef Microbes. 2018;9:697. doi:10.3920/BM2017.0105
- Leventogiannis K, Gkolfakis P, Spithakis G, Tsatali A, Pistiki A, et al. Effect of a Preparation of Four Probiotics on Symptoms of Patients with Irritable Bowel Syndrome: Association with Intestinal Bacterial Overgrowth. Probiotics Antimicrob Proteins. 2019;11:627. doi:10.1007/s12602-018-9401-3
- Sadrin S, Sennoune SR, Gout B, Marque S, Moreau J, et al. Lactobacillus acidophilus versus placebo in the symptomatic treatment of irritable bowel syndrome: the LAPIBSS randomized trial. Cell Mol Biol (Noisy-le-grand). 2017;63:122. doi:10.14715/cmb/2017.63.9.21
- Bogovič Matijašić B, Obermajer T, Lipoglavšek L, Sernel T, Locatelli I, et al. Effects of synbiotic fermented milk containing Lactobacillus acidophilus La-5 and Bifidobacterium animalis ssp. lactis BB-12 on the fecal microbiota of adults with irritable bowel syndrome: A randomized double-blind, placebo-controlled trial. J Dairy Sci. 2016;99:5008. doi:10.3168/jds.2015-10743
- Yoon H, Park YS, Lee DH, Seo JG, Shin CM, et al. Effect of administering a multi-species probiotic mixture on the changes in fecal microbiota and symptoms of irritable bowel syndrome: a randomized, double-blind, placebo-controlled trial. J Clin Biochem Nutr. 2015;57:129. doi:10.3164/jcbn.15-14
- Shanshal SA, Alsaaty MH, Al-Qazaz H, Al-Zidan RN. Two Lactobacilli strains as adjuvant therapy in the management of irritable bowel syndrome: a randomized control trial. Ceska Slov Farm. 2024;73:233.
- Shin SY, Park S, Moon JM, Kim K, Kim JW, et al. Compositional Changes in the Gut Microbiota of Responders and Non-responders to Probiotic Treatment Among Patients With Diarrhea-predominant Irritable Bowel Syndrome: A Post Hoc Analysis of a Randomized Clinical Trial. J Neurogastroenterol Motil. 2022;28:642. doi:10.5056/jnm21202
- Yoon JS, Sohn W, Lee OY, Lee SP, Lee KN, et al. Effect of multispecies probiotics on irritable bowel syndrome: a randomized, double-blind, placebo-controlled trial. J Gastroenterol Hepatol. 2014;29:52. doi:10.1111/jgh.12322
- JanssenDuijghuijsen L, van den Belt M, Rijnaarts I, Vos P, Guillemet D, et al. Acacia fiber or probiotic supplements to relieve gastrointestinal complaints in patients with constipation-predominant IBS: a 4-week randomized double-blinded placebo-controlled intervention trial. Eur J Nutr. 2024;63:1983. doi:10.1007/s00394-024-03398-8
- Skrzydło-Radomańska B, Prozorow-Król B, Kurzeja-Mirosław A, Cichoż-Lach H, Laskowska K, et al. The Efficacy and Safety of Single-Strain Probiotic Formulations Containing or in Adult Patients with Irritable Bowel Syndrome-A Randomized Double-Blind Placebo-Controlled Three-Arm Interventional Trial. J Clin Med. 2023;12. doi:10.3390/jcm12144838
- Boonma P, Shapiro JM, Hollister EB, Badu S, Wu Q, et al. Probiotic VSL#3 Treatment Reduces Colonic Permeability and Abdominal Pain Symptoms in Patients With Irritable Bowel Syndrome. Front Pain Res (Lausanne). 2021;2:691689. doi:10.3389/fpain.2021.691689
- Xu H, Ma C, Zhao F, Chen P, Liu Y, et al. Adjunctive treatment with probiotics partially alleviates symptoms and reduces inflammation in patients with irritable bowel syndrome. Eur J Nutr. 2021;60:2553. doi:10.1007/s00394-020-02437-4
- Szajewska H, Hojsak I. Health benefits of GG and subspecies BB-12 in children. Postgrad Med. 2020;132:441. doi:10.1080/00325481.2020.1731214
- Le Nevé B, Derrien M, Tap J, Brazeilles R, Cools Portier S, et al. Fasting breath H2 and gut microbiota metabolic potential are associated with the response to a fermented milk product in irritable bowel syndrome. PLoS One. 2019;14:e0214273. doi:10.1371/journal.pone.0214273
- Baştürk A, Artan R, Yılmaz A. Efficacy of synbiotic, probiotic, and prebiotic treatments for irritable bowel syndrome in children: A randomized controlled trial. Turk J Gastroenterol. 2016;27:439. doi:10.5152/tjg.2016.16301
- Eskesen D, Jespersen L, Michelsen B, Whorwell PJ, Müller-Lissner S, et al. Effect of the probiotic strain Bifidobacterium animalis subsp. lactis, BB-12®, on defecation frequency in healthy subjects with low defecation frequency and abdominal discomfort: a randomised, double-blind, placebo-controlled, parallel-group trial. Br J Nutr. 2015;114:1638. doi:10.1017/S0007114515003347
- Veiga P, Pons N, Agrawal A, Oozeer R, Guyonnet D, et al. Changes of the human gut microbiome induced by a fermented milk product. Sci Rep. 2014;4:6328. doi:10.1038/srep06328
- Gomes P, Laroute V, Beaufrand C, Bézirard V, Aubry N, et al. Postbiotic potential of Lactococcus lactis CNCM I-5388 in alleviating visceral pain in female rat through GABA production: The innovative concept of the "active-GAD bag". FASEB J. 2025;39:e70383. doi:10.1096/fj.202401125RR
- Gomes P, Laroute V, Beaufrand C, Daveran-Mingot ML, Aubry N, et al. Lactococcus lactis CNCM I-5388 versus NCDO2118 by its GABA hyperproduction ability, counteracts faster stress-induced intestinal hypersensitivity in rats. FASEB J. 2023;37:e23264. doi:10.1096/fj.202301588R
- Laroute V, Beaufrand C, Gomes P, Nouaille S, Tondereau V, et al. NCDO2118 exerts visceral antinociceptive properties in rat via GABA production in the gastro-intestinal tract. Elife. 2022;11. doi:10.7554/eLife.77100
